Mathematical Virology: Geometry as a key to discover novel anti-viral solutions, a talk by Professor Reidun Twarock (University of York)
Abstract
Viruses encapsulate their genetic material into protein containers that act akin to molecular Trojan horses, protecting viral genomes between rounds of infection and facilitating their release into the host cell environment. In the majority of viruses, including major human pathogens, these containers have icosahedral symmetry, and many open questions in virology can therefore be addressed through the lens of viral geometry. In this talk, I will demonstrate that mathematical techniques from group, graph, tiling and lattice theory, in partnership with biophysical modelling, bioinformatics, stochastic simulations and experiment, can act as drivers of discovery in virology. The talk will finish with a discussion of how this geometric and mechanistic understanding of viral infections has opened up novel avenues in anti-viral therapy, vaccination and gene therapy.
This talk will be given remotely, via Zoom. If you wish to register for attendance at this West Midlands branch talk, please contact Gemma Reeves before 3.00pm on the day of the talk, who will provide the required details.
No charge is made to attend meetings. Non-IMA members are welcome.
